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EU-FP 7: ORBIVAC - Development of Vaccines for bTV, EHDV and AHSV
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PROJEKT: The major outstanding challenges of orbi-virus vaccine research is to develop vaccines that can afford a broad protective immune response against as many serotypes of each virus as possible, and to develop a high throughput DIVA assay (e.g. an ELISA). This project will use a coordinated multi-partner approach to address these issues, to develop new experimental prototype vaccines and diagnostic approaches.
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It will build on specific expertise and reagents that are only available within the consortium and will link out to other international efforts in USA and South Africa to develop improved vaccines for these diseases. The consortium includes a number of industrial partners who are already active in vaccine manufacture for these and other veterinary diseases, in order to ensure that the findings of the research are transferred as soon as possible into commercial vaccines for European livestock. The project also includes two SMEs, who will be specifically involved in the development of DIVA compatible diagnostic tests.
In summary, the specific objectives of the project will be: to develop multivalent vaccines using different approaches for Orbi-viruses responsible for livestock diseases, in particular, Bluetongue Virus (BTV), African Horse Sickness Virus (AHSV) and Epizootic Haemorrhagic Disease Virus (EHDV); to understand the best vaccination strategy to elicit multi-serotype protection for these viruses in livestock and analyze immune responses for each of the novel vaccines developed for breadth of protection against multiple serotypes; and to develop DIVA compatible diagnostics that will work with the new vaccines developed in order to differentiate between vaccinated and infected animals.
Partner
 | LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE, UNITED KINGDOM (Coordinator)
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| BOEHRINGER INGELHEIM VETMEDICA, GERMANY
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| FORT DODGE VETERINARIA, S.A., SPAIN
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| ID VET SARL , FRANCE
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| DELTAMUNE (PTY) LTD, SOUTH AFRICA
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| INTERVET INTERNATIONAL B.V., NETHERLANDS
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| KANSAS STATE UNIVERSITY, UNITED STATES
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| THE INSTITUTE FOR ANIMAL HEALTH, UNITED KINGDOM
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| MERIAL SAS, FRANCE
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| FRIEDRICH LOEFFLER INSTITUT - BUNDESFORSCHUNGSINSTITUT FUER TIERGESUNDHEIT, GERMANY
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| CENTRUM VOOR ONDERZOEK IN DIERGENEESKUNDE EN AGROCHEMIE – CODA, BELGIUM
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| CENTRE DE COOPERATION INTERNATIONAL EN RECHERCHE AGRONOMIQUE POUR LE DEVELOPPEMENT, FRANCE
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| STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK, NETHERLANDS
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| AGENCE FRANCAISE DE SECURITE SANITAIRE DES ALIMENTS, FRANCE
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| UNIVERSIDAD COMPLUTENSE DE MADRID, SPAIN
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| INMUNOLOGIA Y GENETICA APLICADA SA, SPAIN
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Project details
Start Date: 2010-02-01
End Date: 2013-01-31
Duration: 36 months
Project Reference: 245266
Project Funding: 3 million euro
Source: Cordis
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