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Michael O. Glocker studied Chemistry at the University of Konstanz, Germany, where he graduated in Organic Chemistry. During his Ph.D. studies with Johannes C. Jochims he focussed on the synthesis and characterization of small molecules that play a role in major industrial processes such as Nylon synthesis. He received his Ph.D. degree in 1990.
Subsequently, he went to the United States as Post-doctoral fellow and joined the mass spectrometry laboratory of the Oregon State University, headed by Max L. Deinzer. Here he analyzed natural products of hops and helped installing the newly set-up protein mass spectrometry group. Within that time he shifted his scientific interest to the analysis of protein disulfide bond structures using mass spectrometric methods.
He returned to Germany in 1992, joining Michael Przybylski´s group at the Analytical
Chemistry Department of the University of Konstanz, and started to work on his Habilitation in 1994. He finished his Habilitation in 1997, in which he combined bioanalytical methods, particularly modern mass spectrometry techniques, with biochemical protein modification reactions to analyze protein structures, protein-protein interactions, and protein folding intermediates.
Soon thereafter, he received the call from the University of Rostock for the appointment of the first German professorship devoted to “Proteome research” which he accepted in 1999. Since then he is director of the Proteome Center Rostock, a newly established research facility at the Medical Faculty of the University of Rostock.
This Center is dedicated to the molecular characterization of diseases by making use of platform methodologies such as transcriptomics, proteomics, and bioinformatics. The Proteome Center Rostock provides expertise in global proteomics and structural proteome analysis including high resolution separation technologies such as 2DE gel electrophoresis and mass spectrometric characterization of proteins and protein modifications. Proteome and transcriptome data are comprehensively stored via the bioinformatics group of the Proteome Center Rostock using the in-house developed “ProteoBase”, a fully functional LIM-system and results data base. This data base functions as strong bioinformatics source as it enables “plug-ins” for many bioinformatic research tools.
Michael O. Glocker´s current research is focused on (i) investigations of proteomes from clinical patients suffering from multigenic diseases and includes suitable model systems, and (ii) the development of advanced mass spectrometric methods in conjunction with biochemical modification reactions for the characterization of protein structures, protein folding reactions, protein degeneration processes, protein modifications, and protein-protein interactions. Detailed characterization of post-translational modifications are performed for the determination of regulatory and signaling pathways in a Systems Biology approach. These major activities encompass strong research and development efforts in conjunction with partners from academia and private industry (e.g. QIT-TOF-MSn; The first instrument of its
type in Europe; Shimadzu Deutschland) in order to develop new technologies and methods for detailed mass spectrometric protein structure characterizations.
Michael O. Glocker is co-founder of the German Society for Proteome Research (DGPF), and member in The German Chemical Society (GDCh), The German Society for Mass Spectrometry (DGMS), The American Society for Mass Spectrometry (ASMS), The European Peptide Society (EPS), The Swiss Proteomics Society (SPS), and The German Society for Electrophoresis (DEG). He is referee for numerous scientific journals and member of the editorial board of the “European Journal of Mass Spectrometry”.
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