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The ANDANTE project will investigate the relative risk of neutrons compared to photons for tumourigenesis, as a function of dose and energy. The approach will be multidisciplinary, including physics measurements and modelling, molecular biology, radiobiology, and epidemiology. The relative risk of neutrons will be studied using human and animal stem cells irradiated with either photons or neutrons in vitro and analysed for early indicators of malignant transformations. Irradiated stem cells will be transplanted into mice to investigate progression into tumours. The experimental irradiation setup will be fully characterised and modelled in order to compare predicted molecular damage with biological results, following controlled irradiation with either photons or neutrons. A corresponding predictive model of the relative risk of cancer induction from photons or neutrons following paediatric radiotherapy will be developed and tested on clinical data, as a proof of principle, leading to a proposal for a prospective epidemiological study to validate the relative risk of neutrons on humans.
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Project details:
Project Acronym: ANDANTE
Start Date: 2012-01-01
End Date: 2015-12-31
Project Funding: 3 million euro
Coordinator:
UNIVERSITA DEGLI STUDI DI PAVIA
PAVIA ITALY
Participants:
CHALMERS TEKNISKA HOEGSKOLA AB, SWEDEN
LOMA LINDA UNIVERSITY, UNITED STATES
UNIVERSITAET ROSTOCK, GERMANY
BUNDESAMT FUER STRAHLENSCHUTZ, GERMANY
EUROPEAN SOCIETY FOR THERAPEUTIC RADIOLOGY AND ONCOLOGY, BELGIUM
ACADEMISCH ZIEKENHUIS GRONINGEN, NETHERLANDS
PAUL SCHERRER INSTITUT, SWITZERLAND
Contact:
Prof. Dr. med. G. Hildebrand
Universität Rostock
Klinik und Poliklinik für Strahlentherapie
Labor für Strahlenbiologie
Südring 75
18059 Rostock
Tel. +49-381-494-9110
Fax. +49-381-494-9002
www.strahlentherapie.med.uni-rostock.de/
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