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DFG-Forschergruppe 1186 Photorespiration: Origins and Metabolic In¬tegration in Interacting Compartments (Promics), Teilprojekt 10: Investigation of photorespiratory metabolism by mathematical modeling
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PROJEKT: The PROMICS addresses the cellular biology and metabolic integration of photorespiratory processes in the context of carbon metabolism (C3, C4 and cyanobacteria), stress response and productivity. Photorespiration occurs in all oxygen-based photosynthetic organisms.
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The main question arises where is the balance between the stress protection and crop yield or if the photorespiration is essential process at all. The subquestion we are focused on is: How is the photorespiration regulated and integrated among other processes in the context of carbon metabolism within the range of phylogenetically different organisms (C3 and C4 plants and cyanobacteria)?
The photorespiration cycle is known decades but not all components are known and our understanding of interaction with other major metabolic pathways is also limited. In order to improve our knowledge about the photorespiration, extensive collaborating is needed. Our department is employed in the Systems Biology approach of the project which allows integration of multi-level experimental data into a central computational model.
The project is in its initial stage. We started with the basic scheme model of the Calvin-Benson cycle and starch synthesis and compared the outputs of our model with the simulations based on the earlier models of the dark photosynthetic reactions. This comparison proved serious errors in the earlier models. We described these errors and suggested the corrections. The next step is to develop a model of photosynthetic reactions for cyanobacteria.
There are several main goals of PROMICS in which solving the Systems Biology is involved:
1) construction of the canonical model of photosynthetic-photorespiratory carbon metabolism
2) analysis of photorespiratory metabolism in a range of phylogenetically different organisms
3) identification of unknown components of photorespiratory metabolism with the help of overexpressor and knockout lines
4) model interrogation and validation, formulating of new hypotheses
Project Duration: 01.07.2009 - 30.06.2012
Contact:
Systems Biology & Bioinformatics Group
University of Rostock
18051 Rostock, Germany
Secretariat
Mrs Peggy Sterling
Mail: peggy (dot) sterling (at) uni-rostock (dot) de
Tel.: +49 (0)381 498 75 71
Fax.: +49 (0)381 498 75 72 (or 74 52 but with a notice to direct it to us)
In case of problems try the research staff under +49 (0)381 498 75 74/75 or +49 (0)381 498 75 76.
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