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Herr Prof. Dr. Dieter G. Weiss
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Prof. Weiss is a biologist specializing in biochemistry and neurobiology. He did his Ph-D work on transmitter-specificity of synaptic vesicles at Psychopharmacology Unit (Prof. N. Matussek) of the Max Planck Institute for Psychiatry, Munich. After working on various neurochemistry and cell biolgy topics as leader of independent research groups at the Institutes of Zoology at University of Munich and at Technical University Munich he works since 1993 as Full Professor for Animal Physiology at University of Rostock. He contributed techniques for live cell imaging of neurons and for multiparametric analysis of neuronal cell ensembles on micro-electrode arrays. The technology is based on years of previous research analyzing the electrical activity pattern changes caused by transmitter receptor agonists and antagonists. Active compounds are added to the neurosensor chip cultures and the quantitative analysis of the electrical pattern changes is used to identify the compound class, the target receptor types and to give an indication for potential clinical relevance of the tested condition. The system has been already successfully applied for high-content screening in studies of selected alkaloide analgesics, anesthetics and anticonvulsive compounds.
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